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What Is Retinoblastoma?

Retinoblastoma Is A Cancer

Of The Eye In Children. It Originates From The Retina, The Light Sensitive Layer, In Eye. It Is The Commonest Eye Tumor Of The Eye In Childhood. . This Tumor May Involve One (75% Of Cases) Or Both (25% Of Cases) Eyes In A Child. Untreated, Retinoblastoma Is Almost Always Fatal, Hence The Importance Of Early Diagnosis And Treatment

Is It Hereditary?

Yes In Some Cases It May Be Hereditary. Majority Of Cases (90%) Has No Family History Of Such Disease; While A Small Percentage (10%) Of Newly Diagnosed Cases Have Other Family Members With Retinoblastoma.

Of All The Cases Of Retinoblastoma, In 60% Of Cases It Does Not Get Transmitted To The Next Generation, While In 40% Of Cases It May Get Transmitted In The Next Generation. Therefore It Is Important To Have A Genetic Counseling Before Having A Baby To Determine The Risk Of Another Child Getting The Same Disease. Also, The Siblings And Children Of The Patients With Retinoblastoma Should Be Examined Periodically In Their Childhood To Detect Any Possible Tumor Early.

What Are The Symptoms Of Retinoblastoma?

As The Child Does Not Complain Of Any Poor Vision, The Tumor May Remain Undetected. The Most Common Way Of Presentation Is A White Reflex (Leukocoria) Behind The Pupil. This Is Sometimes Called The Cat's Eye Reflex. There May Be Other Causes Of This White Reflex As Well, But An Evaluation By An Ophthalmologist Is A Must In All These Children To Rule Out The Possibility Of This Serious And Potentially Life Threatening Disease.

It May Also Present As Squint (Crossed Eye), Poor Vision, Painful Red Eye, Inflammation Of The Tissue Surrounding Eye, Protrusion Of The Eye Ball (Proptosis) Etc. Occasionally It Is Detected On A Routine Eye Checkup By An Ophthalmologist, Especially In A Child With Family History Of This Disease.

Retinoblastoma Treatment, Retinoblastoma Treatment India, Symptoms Of Retinoblastoma

How Can It Be Detected Early?

The Most Common Time Of Detection Of This Tumor Is Around One Year Of Age, When Both Eyes Are Involved; And Around Two Years Of Age When Only One Eye Is Involved. A Periodic Evaluation Of The Child By An Ophthalmologist, Especially If There Is A Family History Of This Disease May Help In Picking Up The Tumor Early. Whenever The Child Is Suspected To Have Poor Vision Or If There Are Any Of The Above Symptoms Noted, An Ophthalmologist Must Be Consulted.

To Establish The Diagnosis, The Doctor May Need To Examine The Child Under General Anesthesia. A Few Special Tests Like Ultrasonography, CT Scan, X-Rays, MRI, Blood Tests, Spinal Tap, Bone Marrow Biopsy Etc. May Be Done To Establish The Diagnosis And To Find Out The Extent Of The Disease.

What Are The Treatment Options?

The Aim Of Treatment In Retinoblastoma, In Order Of Priority, Is To Save The Life, Eye, Sight And Cosmesis Of The Child.
There Are Many Treatment Modalities For This Tumor. These Are:
  • Enucleation: This Means Removal Of The Eye. The Eye With The Tumor Is Removed And Is Sent For A Pathology Report. The Space Is Replaced By An Artificial Implant Made Of Plastic, Rubber Or Coral. The Child Is Fitted With Prosthesis Or Artificial Eye, Made To Match The Other Eye. This Artificial Eye, Of Course, Does Not Have Any Vision.
  • External Beam Radiation: As An Alternative To Enucleation, This Method Of Giving Radiation Treatment To The Eye May Treat The Tumor While Preserving The Eye. As The Tumor Is Very Radiosensitive, This Treatment Method Is Very Effective. Though The Radiation May Cause Damage To The Surrounding Structures Of The Eye, E.G., Lens (Cataract), Lacrimal System (Dry Eye), Orbit (Bone Maldevelopment) Etc. It Also Increases The Chance Of Developing Secondary Tumor Of The Bone, Especially In Children With Tumor Involving Both Eyes.
  • Localized Plaque Radiation Therapy: This Method Involves Applying Radioactive Plaque Close To The Tumor On The Sclera, And Thus Gives The Radiation Therapy In A Localized Area. It Significantly Decreases The Local Complications Associated With Radiation Therapy.
  • Photocoagulation: Laser Treatment For The Tumor Is Effective And Safe For Tumors That Are Smaller In Size. In The Right Cases, This Treatment May Help In Preserving Eye As Well As The Sight Of The Child.
  • Cryotherapy: This Involves Freezing Of The Tumor By Applying A Special Probe On The External Surface Of The Eye (Sclera). This Treatment Is Done Under Direct Observation And Is Effective In Saving The Eye And Sight In Patients With Small Tumor.
  • Chemotherapy: Treatment With Anticancer Drugs. There Has Been A Recent Preference Towards Treatment With Systemic Drugs As An Additional Treatment. The Chemotherapy May Decrease The Size Of The Tumor And Thus Make It More Amenable To Local Treatment Like Laser, Cryotherapy And Plaque Radiation.

Which Treatment Option Is The Best?

The Treatment Of Retinoblastoma Is Individualized For Each Patient. The Treatment Modality For A Given Child Is Decided Based On Many Important Factors. These Are:
  • Size Of The Tumor
  • Location Of The Tumor
  • Whether The Tumor Has Spread
  • Status Of The Other Eye
  • Associated Complications Like Retinal Detachment, Glaucoma
  • Family History
  • The Wishes And Concerns Of The Parents
  • Availability Of The Facilities
As This Is A Difficult Decision Made Based On Many Factors, It Is Advised To Discuss With The Treating Ophthalmologist About The Best Treatment Option For The Concerned Child.

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