What is Parathyroid Cancer ?
Parathyroid cancer is quite rare, and the majority of parathyroid tumors are benign adenomas, meaning they are not cancerous. Both benign and malignant parathyroid tumors increase blood levels of parathyroid hormone and wreak havoc on calcium levels. Malignant tumors tend to cause the largest increase in parathyroid hormone, yet only about oner percent of people who see their doctor for hyperparathyroidism have cancerous tumors.
Treating Parathyroid CancerSurgery to remove the affected gland is the mainstay of treatment for parathyroid cancer. Radiation therapy and chemotherapy are very rarely used. In most cases only one of the four parathyroid glands is cancerous.
CausesThe parathyroid glands are responsible for controlling the calcium in the body. There are four parathyroid glands, two on each lobe of the thyroid gland. They are located at the base of the neck.
Parathyroid cancer is an extremely rare type of cancer. Men and women are equally affected. It usually occurs in people older than 30.
The cause of parathyroid cancer is unknown. People with multiple endocrine neoplasia type I have an increased risk for this disease. People who had head or neck radiation may also be at increased risk. Such radiation exposure, however, is more often connected with thyroid cancer.
SymptomsSymptoms of parathyroid cancer are primarily caused by high levels of calcium in the blood (hypercalcemia), and may affect various parts of the body. They include: -
- Abnormal fractures
- Bone pain
- Frequent thirst
- Frequent urination
- Kidney stones
- Muscle weakness
- Poor appetite
It is important to note that primary hyperparathyroidism is a much more common cause of these symptoms, and most patients with these symptoms do not have parathyroid cancer.
Exams and TestsParathyroid cancer is extremely hard to diagnose.
Your doctor will perform a physical exam and ask about your medical history.
In about half of all cases, feeling the neck with the hands (palpation) can reveal a cancerous parathyroid tumor.
Cancerous parathyroid tumors tend to produce very high amounts of parathyroid hormone (PTH).
Tests may include: -
- Serum calcium (levels higher than 14 mg/dL are suspicious)
- Serum PTH (levels that are more than twice than normal may indicate cancer)
TreatmentThe following treatments may be used to correct hypercalcemia due to parathyroid cancer: -
- A drug that lowers levels of calcium in the blood (gallium nitrate)
- A natural hormone produced by the body that helps control calcium levels (calcitonin)
- Drugs that stop the destruction and reabsorption of bones into the body, such as pamidronate or etidronate (bisphosphonates)
- Fluids through a vein (IV fluids)
If tests before the surgery can find the suspicious gland, surgery may be done on one side of the neck (unilateral). If it is not possible to find the problem gland before surgery, the surgeon will look at both sides of your neck.
Chemotherapy and radiation do not work very well in preventing the cancer from coming back, although radiation can sometimes help reduce the spread of cancer to the bones. Repeated surgeries for cancer that has returned may increase survival rate and reduce the severe effects of hypercalcemia.
Minimally invasive surgery, using smaller cuts, is becoming more common for parathyroid disease.
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