Overview
Pediatric hematologists and other experts at Mayo Clinic in Rochester practice a multidisciplinary approach to treating white blood cell disorders. Physicians and allied health staff work together to provide exceptional care for the child and support for the family.
White blood cells help the body fight bacterial infections, viruses and fungi. Also called leukocytes, white blood cells are made up of five subtypes, including neutrophils, eosinophils, basophils, monocytes and lymphocytes. The human body normally produces about 100 billion white blood cells each day.
Causes
- Many of the exact functions of the gene products that are mutated in partial T-cell disorders have yet to be elucidated.
- For a more complete discussion of the genes responsible for DGS, AT, WAS, and CHS, and the specific articles for each disorder.
- CHS is caused by mutations in the gene encoding for the lysosomal-trafficking regulator. This mutation leads to abnormal distribution of lysosomal proteins in phagocytes (impairing bactericidal activity), in melanosomes (explaining partial albinism), and in neurologic function and to cytotoxicity by T cells and natural killer (NK) cells, predisposing patients to aberrant responses to EBV and leading to the accelerated phase.
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